Effect of Fasudil in Patients with Chronic Heart Failure
Abstract： Objective:To explore the difference of brain natriuretic peptide(BNP) concentration and clinical effects in patients with chronic heart failure who received Fasudil treatment.Methods:One hundred chronic heart failure patients with cardiac function(NYHA)Ⅲ-Ⅳwere randomly divided into the treatment group(n=50) and the control group(n=50).The two groups were given conventional treatment,including diuretics,oral angiotensin-converting enzyme inhibitors, digoxin.Patients in treatment group on the basis of this treatment were treated with Fasudil 60 mg/d.The plasma levels of BNP was detected,LVEF and CO were observed by echocardiography,and the exercise endurance were evaluated by 6-minutes walking test before and after the treatment.Results:The plasma levels of BNP,left ventrieular function(LVFF) and the distance of 6-minutes walking test were significantly improved after therapy in two groups(P<0.01),especially in the treatment group(P<0.05).The concentrations of BNP in treatment group were significantly decreased(398.2±105.3)/(456.5±106.4)ng/L(P<0.05).LVEF of the patients in treatment group were increased significantly(53.4±9.9)/(46.5±8.3)%(P<0.05).The distance of 6-minutes walking test of the patients in the treatment group were also significantly increased(419.2±71.6)/(382.5±53.7)m(P<0.05).Conclusion:Fasudil can significantly improve cardiac function and decrease plasma BNP level of chronic heart failure patients.
Keywords：FasudilChronic heart failureBrain natriuretic peptide6-minutes walking test
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 6-8 )