Increased Circulating Level of Chemerin in Patients with Chronic Systolic Heart Failure
Abstract： Objective:To compare plasma Chemerin levels in patients with chronic heart failure(CHF) and in control subjects,and assesse the association of plasma Chemerin with body composition and metabolic parameters in these subjects.Methods:Serum Chemerin and Tumor Necrosis Factor-α(TNF-α) levels were measured by ELISA in 52 patients with CHF and in 52 age,tender,diabetes-history matched controls with cardiovascular disease but normal heart function, and in 26 healthy volunteers.Furthermore,the association between chemerin and NT-proBNP,TNF-α as well as metabolism markers were studied. Results:Plasma Chemerin levels were found to be markedly increased in patients with CHF as compared with patients without CHF and normal controls(P<0.001). Multiple regression analysis showed that TG(r=0.270,P=0.021),body mass index(r=0.250,P=0.029),HOMA-IR(r=0.319,P=0.005) and TNF-α(r=0.348, P=0.003) were independently related factors influencing plasma Chemerin levels.Conclusion:The present work indicates the potential role of Chemerin in the pathogenesis of chronic heart failure through the immune response.
Keywords：Chronic heart failureChemerinAdipocytokineTumor necrosis factor-αNT-proBNP
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-3,4 )