The Effects of Mifepristone on the Expression of IGF-1 in Sera of Patients with Myoma of Uterus
HOU Hong-li
Abstract： Objective:To study the effects of mifepristone on the expression of IGF-1 in sera of patients with myoma of uterus.Methods:52 patients with one tumor body greater than or equal to 3 mm at least,who oraled mifepristone 25 mg per day for taking 3 months since fifth days of menstruation,the serum concentrations of IGF-1 were determined at different time points after taking mifepristone,uterine fibroid volume were detected with B ultrasound before and after taking mifepristone at the same time,the control group was premenopausal patients of hysteromyoma.Results:IGF-1 were significant statistical difference compared treated group with control group in different times(P<0.01);there were significant statistical difference compared treated group in 1.5 month with other different times(P<0.01);there were no significant statistical difference compared mifepristone treated groups in 2,2.5,and 3 months(P>0.05).Myoma volume in treated group was significantly reduced after taking medicine compared with the control group(P<0.01).There was a strong positive correlation between serum IGF-1 decrease after taking mifepristone with uterus myoma shrink.Conclusion:Mifepristone can effectively reduce the expression of IGF-1 in serum of patients with hysteromyoma.
Keywords：MifepristoneInsulin like growth factor 1Hysteromyoma
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3-4,5 )