Clinical Research about the Effect of Glucosamine on the Lever of IL-6,VEGF,SOD and MDA in the Patients with Knee Osteoarthritis

doi:10.3969/j.issn.1674-6805.2013.19.006

Abstract： Objective:To observe the change of levels of interleukin-6(IL-6),vascular endothelial growth factor(VEGF),superoxide dismutase(SOD) and malondialdehyde(MDA) in the synovial fluid of patients with knee osteoarthritis,and the effect of Glucosamine on the levers of IL-6,VEGF,SOD and MDA. Methods:76 patients with knee osteoarthritis were randomly divided into group A(regular treatment group) and group B(glucosamine treatment group).The patients in the group A were given regular treatment,while the patients in the group B were treated with regular protocals and Oraling glucosamine capsule for 8 weeks. The patients of two groups were discontinued nonsteroidal anti-inflammatory drugs after two weeks,and punctured and sucked synovial fluid of knee cavity.Before and after the treatment,the levels of IL-6 and VEGF in synovial fluid of the two groups were detected.We evaluated the curative effect according to the results. Results:The levels of IL-6,VEGF,SOD and MDA in two groups were no difference before treatment(P>0.05),while the levels of IL-6 and VEGF were both reduced significantly after treatment,and significantly different between two groups(P<0.05).The level of SOD in two groups were both increased significantly,but the levels of MDA were reduced significantly,and there were significantly different comparing between two groups(P<0.01).Conclusion:The relationship of the levels of IL-6 and VEGF in the synovial fluid and the occurrence and development of osteoarthritis are very closed,the content of IL-6 and VEGF and clinical symptoms are positively correlated.Relationship of the levels of SOD and MDA in the synovial fluid and the occurrence and development of osteoarthritis is very closed,the content of SOD and MDA and clinical symptoms are positively correlated.Glucosamine can reduce the levels of IL-6 and VEGF in the synovial fluid of patients with knee osteoarthritis,alleviate inflammation,so as to improve the clinical symptoms.Glucosamine can increase the level of SOD and reduce the lever of MDA in the synovial fluid of patients with knee osteoarthritis,alleviate inflammation,so as to reduce Lequesne index and improve the clinical symptoms,and the effect of the conventional group is obvious.This may be one of the mechanism of action of glucosamine hydrochloride in osteoarthritis.