Analysis on Antibiotics Resistance of Common Gram-negative Bacilli in Nosocomial Infection

Abstract：Objective:To investigate the incidence of the clinical isolates gram-negative bacilli and monitor the drug resistance surveillance.Methods:Collecting a total of 5548 non-duplicate clinical isolates of Gram-negative bacteria in 2011-2012.The identification of bacteria and susceptibility test were performed using VITEK2 automatic bacteria idenificator.Results:Pseudomonas aeruginosa(32.7%),escherichia coli(23.6%),acinetobacter baumannii(23.0%),pneumonia gramsReber bacteria (6.9%),proteus mirabilis(5.3%) were most frequently isolated.Escherichia coli,klebsiella pneumoniae,proteus mirabilis in ESBLs positive rate were 48.4%,31.8%and 13.4%,ESBLs producing strains were the important pathogens of nosocomial infection;Imipenem and meropenem resistant strains were not found.The susceptibility rates of pseudomonas aeruginosa to meropenem,imipenem,cefoperazone-sulbactam,amikacin,tobramycin,piperacillin-tazobactam respectively were 81.3%,79.3%,77.0%,67.2%,63.9%,60.9%.The susceptibility rate of Baumanil to minocycline,and cefoperazone-sulbactam were 30.4%and 48.2%.The other antibiotics resistance rate were above 80.0%.Conclusion:Compared to 2010,acinetobacter baumannii is increased,amomn these isolation strains and mostly came from ICU,the sensitive rates of acinetobacter baumannii to imine-south and meropenem is decline,pan-resistant strains account for about 80.0%and drug resistance is serious,a growing trend of the clinical isolates Gram-negative bacilli to common biotics was showed.The detection rate of ESBLs,CRPA and CRAB is increasing significantly.It is the most important and valuable to strength the rational selection of antimicrobial agents and control the nosocomial infections.