The Change and Significance of Serum IL-21 and IL-6 in Patients with Idiopathic Thrombocytopenic Purpura
Abstract：Objective:To study the changes and clinical significances of interleukin 21(IL-21) and interleukin 6(IL-6) in idiopathic thrombocytopenic purpura(ITP) patients between pre and post treatment.Methods:IL-21 and IL-6 were detected by enzyme linked immunosorbent assay (ELISA).Results:The levels of serum IL-21 and IL-6 in pre-treatment ITP patients were obviously higher than normal group(P<0.01);After treatment,the levels were significantly lower than pre-treatment except ineffective group(P<0.01),and higher than normal group(P<0.01);There was no significant difference in newly diagnosed group and ineffective group(P>0.05);The levels were obviously lower in high effective group,moderate effective group and improved group than in ineffective group(P<0.01);But there was no difference between moderate effective and improved group(P>0.05).Conclusion:IL-21 and IL-6 might play an important role in the pathogenic process of ITP and the levels are changed with severity and course of the disease.It’s necessary to detect the IL-21 and IL-6 levels regularly to observe the treatment effective and prognosis.
Keywords：Idiopathic thrombocytopenic purpuraInterleukin 21Interleukin 6
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)