Experimental Study of PD-1 Apoptosis in the Pathogenesis of Osteoarthritis
Abstract：Objective:Explore the role of PD-1 in knee osteoarthritis and its correlation with NO.Methods:The study population consisted of 45 cases of patients with osteoarthritis of the knee normal 28 cases,using ELISA determination of PD-1 in the synovial fluid in the expression of the degree of concentration and determination of NO.Results:PD-1 the KOA experimental group and the control group was statistically significant(P<0.01),KOA synovial fluid of patients with significantly higher levels of PD-1. The NO experimental group and control group was statistically significant (P<0.01),significantly higher levels of NO in the synovial fluid of patients with KOA. Experimental group of PD-1 and NO levels Spearman correlation analysis,the correlation coefficient of r=0.915 (P<0.01), and a positive correlation.Conclusion:PD-1 may be an important factor to the KOA pathogenesis promote inflammation of the synovial fluid mediated cartilage degeneration.
Keywords：Knee osteoarthritisSynovial fluidProgram deathNitric oxideApoptosis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)