Effect of Different Crystal Type of Amoxicillin Raw Material on the Stripping Behavior of Preparation
Abstract：Objective:To determine the three drug companies amoxicillin crystal dissolution and in vitro on the crystalline form on dissolution behavior of agents.Methods:By microscope API crystal type,using the USP dissolution determination method for determination of Amoxicillin Capsules in vitro dissolution curves.Results:The 3 enterprises with the same formula preparation of amoxicillin capsule,although 45 minutes of stripping cumulants are consistent with standard requirements,but the dissolution behavior have bigger difference.Conclusion:API crystal type crystal type on drug dissolution had bigger effect,raw material and preparation of new product imitation process should be the solution curves were case-control study,preparation production enterprise production process should pay great attention to the choice of high quality raw materials,the preparation of single point method for the determination of dissolution is not enough to reflect its intrinsic quality.
Keywords：DissolutionMorphologyAmoxicillin raw materials
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)