High Expression Meaning of HSP70 in Hepatic Ischemia-reperfusion Injury Process
Abstract：Hepatic ischemia-reperfusion injury is common pathological physiology phenomenon in liver surgery and liver transplantation. This process involves a lot of important mechanisms,such as microcirculation disturbance,cell apoptosis,inflammation factors release and so on. Simultaneously,in these process we found that intracellular HSP70 expression is increased obviously. Some research shows that HSP70 involved in directly or indirectly the hepatocyte protection and regeneration and improve animals survival after 95%liver resection,which involve a lot of mechanism. The review show how to alleviate liver ischemia-reperfusion injury when HSP70 is at high level,further study about the mechanism of protection will help to reduce liver tissue damage after liver surgery .It is also significance in clinic.
Keywords：HSP70Hepatic ischemia-reperfusion injuryCytoprotective
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)