Effects of Early Enteral Nutrition and Glutamine-supplemented EEN on the Immune Function and Nutritional Metabolism in Old Patients with Severe Acute Pancreatitis
Abstract：Objective:To investigate the effects of early enteral nutrition(EEN) and glutamine -supplemented EEN on the immune function and nutritional metabolism in old patients with severe acute pancreatitis.Methods:40 patients were randomly divided into two groups,normal enteral nutrition group(control group) and glutamine-supplemented EEN group(experimental group).APACHEⅡscore was used to evaluate the patients after admission. Blood samples were colleeted on day 1,7,14 after admission for Tlymphoeyte subsets;Meanwhile,the albumin(ALB),transferring(TF) and nitrogen balance(NB) were also measured.Results:CD3+,CD4+,CD8+value and CD4+/CD8+ratio in both two groups were significantly higher after treatment than that before treatment(P<0.05),and the values of experimental group on day 7,14 after treatment were significantly higher than control group after treatment(P<0.05). ALB and TF were significantly increased in two groups after treatment(P<0.05),negative nitrogen balance converted to positive nitrogen balance(P<0.05);ALB and TF values of experimental group on day 7,14 after treatment were significantly higher than control group after treatment.Conclusion:Glutamine-supplemented EEN can obviously improve the immune function and nutritional metabolism in old patients with severe acute pancreatitis.
Keywords：Severe acute pancreatitisEnteral nutritionGlutamineImmune functionProtein metabolism
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)