Effects of Dezocine on Quality of Emergence from General Anesthesia in the Elderly Patients

Abstract：Objective:To evaluate the effects of dezocine on recovery quality for elderly patients undergoing general anesthesia.Methods:60 cases of elderly patients undergoing abdominal operation,ASA gradeⅠ-Ⅲ,were randomly divided into 3 groups (n=20):group D,group F,and group C.All patients received general anesthesia with continuous infusion of remifentanil,propofol and cisatracurium besylate.At 30 minutes before the end of surgery,patients in D,F and C groups were intravenously injected with 0.1 mg/kg dezocine,and 1μg/kg fentany and 5 ml saline respectively.Spontaneous breathing recovery time (M1),awakening (OAA/S score is 3-4) time (M2) and extubation time (M3) of all patients were recorded.Before and after extubation,systolic blood pressure (SBP), diastolic blood pressure (DBP),heart rate (HR) and riker SAS score of all patients were monitored.At 30 min,1 h,2 h,4 h,and 6 h after extubation,VRS pain score of all patients was observed.Results:M1,M2 and M3 in group D were significantly shorter than that in group F(P<0.05),and were similar with that in group C(P>0.05).At each time point of before and after extubation,SBP,DBP and HR in group D were obviously lower than that in group C,and group F(P<0.05).At the time point of 1 min before and 1 min,5 min after extubation,SBP,DBP and HR in group F was obviously lower than that in group C(P<0.05).At each time point of before and after extubation,riker SAS score in group D were significantly lower than that in group C(P<0.05).At each time point,the score of VRS in group D was significantly lower than that in group C and group F(P<0.05).At the time point of 30 min,1 h and 2 h after extubation,the score of VRS in group F was obviously lower than that in group C(P<0.05).Conclusion:0.1 mg/kg dezocine intravenous injection for elderly patients undergoing general anesthesia can effectively improve the quality of emergence which makes awakening rapid,hemodynamic stable,RSS sedation satisfactory,VAS anelgesia good,side effect decreasing.