Observation on the Efficacy of Non-Invasive Positive Pressure Ventilation Combined with Conventional Therapy in Patients with Acute Heart Failure and Respiratory Failure

YAN Fengying; CAI Huina; TIAN Chengren

doi:10.13919/j.issn.2095-6274.ZHJY202510047

Abstract：Objective To investigate the effects of non-invasive positive pressure ventilation(NIPPV)as an ad-junctive therapy on clinical efficacy,cardiac function,serological markers,and blood gas parameters in patients with severe acute heart failure(AHF)complicated by respiratory failure(RF).Methods Fifty-two patients with severe AHF compli-cated by RF admitted between January 2022 and December 2024 were selected and randomly divided into a control group(n=26)and a study group(n=26)using a random number table.The control group received conventional drug therapy(diu-retics,vasodilators,inotropes,etc.)and oxygen therapy.The study group received NIPPV in addition to the control group's treatment.After 7 days of treatment,clinical efficacy,cardiac index(CI),left ventricular ejection fraction(LVEF),left ventricular end-diastolic dimension(LVEDd),left ventricular end-systolic dimension(LVEDs),serum levels of N-terminal pro-B-type natriuretic peptide(NT-proBNP),C-reactive protein(CRP),cardiac troponin I(cTnI),creatine kinase-MB(CK-MB),and blood gas parameters[oxygenation index(OI),arterial partial pressure of oxygen(PaO₂),oxygen saturation(SpO₂),partial pressure of carbon dioxide(PaCO₂)]were compared between the two groups.Results Before treatment,there were no statistically significant differences in cardiac function,serological,or blood gas parameters between the two groups(P>0.05).After treatment,the study group had higher LVEF and CI,and lower LVEDs and LVEDd than the control group(P<0.05).The study group had higher OI,PaO₂,and SpO₂,and lower PaCO₂ than the control group(P<0.05).The study group had lower serum levels of NT-proBNP,CRP,cTnI,and CK-MB than the control group(P<0.001).The total clinical effective rate was significantly higher in the study group than in the control group(96.15%vs.69.23%,P=0.028).Conclusion On the basis of con-ventional drug therapy,the combined use of NIPPV can more effectively improve clinical symptoms,significantly enhance cardiac function,reduce levels of myocardial injury and inflammatory markers,and rapidly correct hypoxemia and carbon dioxide retention in patients with severe AHF complicated by RF,demonstrating definite clinical efficacy.