Effects of Dexmedetomidine Combined with General Anesthesia on Anesthesia Quality and Hemodynamic Parameters in Acute Cholecystitis Surgical Patients

XU Tao; GAO Rui; LU Manman

doi:10.13919/j.issn.2095-6274.ZHJY202505014

Abstract：Objective To investigate the effects of dexmedetomidine combined with general anesthesia on patients undergoing laparoscopic surgery for acute cholecystitis(AC).Methods A total of 120 patients with acute cholecystitis treated at Shunyi District Hospital,Beijing,from January 2024 to December 2024 were included in the study.They were randomly divided into two groups using a random number table method.The control group(n=60)received general anesthesia,while the observation group(n=60)received general anesthesia plus dexme-detomidine.The anesthesia quality,stress response,hemodynamic parameters,and adverse reactions were analyz-ed.Results The observation group exhibited significantly shorter times for complete nerve block,recovery of spontaneous breathing,and regaining of consciousness compared to the control group(P＜0.001).Preoperative lev-els of cortisol(Cor),adrenaline(E),C-reactive protein(CRP),and tumor necrosis factor-alpha(TNF-α)showed no significant differences between the two groups(P＞0.05).However,at 24 hours postoperatively,these levels were significantly lower in the observation group compared to the control group(P＜0.001).The heart rate and mean ar-terial pressure(MAP)in the observation group at baseline(T0)showed no significant difference compared to the control group(P＞0.05).At subsequent time points,including after intubation(Tl),skin incision(T2),5 minutes after pneumoperitoneum(T3),and at the end of surgery(T4),these parameters were significantly higher in the ob-servation group than in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Dexmedetomidine combined with general anesthesia effectively improves anesthesia quality,reduces the body's stress response,maintains hemodynamic stability,and demonstrates a high level of safety.