Effects of Anisodamine Combined with Fluid Resuscitation on Microcirculation and Hemodynamics in Patients with Septic Shock
MA Xuelian
MA Tao
ZHANG Jiangong
ZHANG Wenxu
HUANG Zhandong
Abstract：Objective To investigate the efficacy of anisodamine combined with fluid resuscitation in the treatment of septic shock.Methods A retrospective analysis was conducted on 62 patients with septic shock admitted to our hospital from March 2022 to December 2024.Based on treatment differences,the patients were di-vided into two groups:the control group received fluid resuscitation alone,while the observation group received an-isodamine combined with fluid resuscitation.Microcirculatory parameters,hemodynamic indices,and clinical out-comes were compared between the two groups.Results At 24h and 72h post-treatment,the observation group exhibited significantly higher mixed venous oxygen saturation(SvO2)(P＜0.05),lower blood lactate levels(P＜0.05),and shorter capillary refill time(CRT)(P＜0.05)compared to the control group.At 24h post-treatment,the observa-tion group demonstrated significantly higher mean arterial pressure(MAP),central venous pressure(CVP),cardiac index(CI),and systemic vascular resistance index(SVRI)(P＜0.05).By 72h post-treatment,the observation group showed significantly lower APACHE Ⅱ and SOFA scores(P＜0.001).Conclusion Anisodamine combined with fluid resuscitation improves microcirculation,restores hemodynamic stability,and promotes clinical recovery in pa-tients with septic shock.
Keywords：Septic shockAnisodamineFluid resuscitationMicrocirculation
Publication Date：2025-07-28
Online Publishing Date：2025-12-02(First online date of this platform, not the publication date of the document)
Pages：4( 813-816 )