Study on the Correlation Between NT-pro BNP,Hcy,Lorenz Scatter Plot,and Prognosis in Elderly Heart Failure Patients

CHEN Mei; HOU Cunqiang; WANG Xiao

doi:10.13919/j.issn.2095-6274.ZHJY202503023

Abstract：Objective To investigate the correlation between N-terminal pro-brain natriuretic peptide(NT-pro BNP),serum homocysteine(Hcy),Lorenz scatter plot,and cardiac function in elderly patients with heart failure,as well as their predictive value for prognosis.Methods A total of 47 heart failure patients admitted to the Department of Geriatric Cardiology of Qingdao University Affiliated Taian Central Hospital from April 2022 to March 2024 were selected as the heart failure group,and another 47 non-heart failure patients hospitalized dur-ing the same period were selected as the control group.All patients underwent testing for NT-pro BNP and Hcy,24-hour dynamic electrocardiogram to obtain arrhythmia types and Lorenz scatter plot,and cardiac ultrasound to obtain left ventricular ejection fraction(LVEF).The levels of NT-pro BNP,Hcy,types and incidence of arrhyth-mia,distribution characteristics of Lorenz scatter plot,and LVEF were compared between the two groups,and their correlations were analyzed.Results The NT-pro BNP level in the heart failure group was higher than that in the control group;the LVEF level in the heart failure group was lower than that in the control group(P＜0.01).There was no significant difference in Hcy between the two groups(P＞0.05).The Lorenz scatter plot in the heart failure group was mainly fan-shaped and irregular,while that in the control group was mainly baseball bat-shaped,with a statistically significant differ-ence(P＜0.05).The incidence of atrial fibrillation and ST-T abnormalities on electrocardiogram in the heart failure group was higher than that in the control group(P＜0.05).The readmission rate in the heart failure group was higher than that in the control group(23.40％vs.14.89％),but the difference was not significant(P＞0.05).ROC curve anal-ysis showed that the area under the curve(AUC)of serum NT-pro BNP for predicting heart failure with reduced ejection fraction was 0.876923,and the AUC of Hey for predicting heart failure with reduced ejection fraction was 0.723104.Pearson correlation analysis showed that NT-pro BNP was negatively correlated with LVEF(r=-0.544),Hey was positively correlated with LVEF(r=0.199),and Lorenz scatter plot(fan-shaped and irregular patterns)was negatively correlated with LVEF(r=-0.221).Conclusion NT-pro BNP,Hey,and Lorenz scatter plot are all correlated with cardiac function and have potential value for combined application,especially in predicting heart failure with reduced ejection fraction and evaluating patient prognosis.