Efficacy of Early Non-invasive Positive Pressure Ventilation in Elderly Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

AN Hongmei; LI Lingyu

doi:10.13919/j.issn.2095-6274.ZHJY202504014

Abstract：Objective To investigate the clinical emergency effects of early non-invasive positive pres-sure ventilation(NIPPV)in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A retrospective study was conducted on 40 elderly patients with acute exacerbation of COPD who were admitted to Sunshine Ronghe Hospital from January 2021 to December 2023.Patients were divided into two groups based on whether they received early NIPPV:the observation group(20 cases receiving early NIPPV+conven-tional emergency treatment)and the control group(20 cases receiving conventional emergency treatment).Pulmonary function indicators,blood gas parameters,degree of dyspnea(mMRC score),clinical symptom improvement,prognos-tic indicators,and incidence of complications were compared between the two groups.Results Before treatment,there were no significant differences between the two groups in terms of FEV1,FVC,FEV1/FVC ratio,PaO2,PaCC2,SaO2,and mMRC score(P＞0.05).After treatment,compared to the control group,the observation group showed sig-nificantly higher levels of FEV1,FVC,FEV1/FVC ratio,PaO2,and SaO2(P＜0.05),and significantly lower levels of PaCC2 and mMRC score(P＜0.05).The observation group also had significantly shorter recovery times for respiratory rate,heart rate,and hospital stay(P＜0.05).The intubation rate,ICU admission rate,and 30-day mortality rate were significantly lower in the observation group(P＜0.05).The overall incidence of complications was significantly lower in the observation group(10.00％vs.40.00％,P＜0.05).Conclusion Early non-invasive positive pressure ventila-tion significantly improves pulmonary function and ventilation in elderly patients with COPD,reduces the need for mechanical ventilation and mortality,and is a safe and effective emergency measure.