The Impact of Different Tidal Volumes on the Efficacy of Invasive Mechanical Ventilation in Patients with Acute Respiratory Failure Without ARDS

HU ChengXin; LIU Fengchun; LIN Min; WU Qixiao; YE Zhangli

doi:10.13919/j.issn.2095-6274.ZHJY202503047

Abstract：Objective To investigate the effect of different tidal volumes during invasive mechanical ven-tilation on the treatment outcomes of acute respiratory failure patients without acute respiratory distress syndrome(ARDS).Methods A retrospective study was conducted on 80 patients with acute respiratory failure who did not have ARDS.They were admitted for treatment from November 2021 to April 2024.After admission,all patients re-ceived invasive mechanical ventilation treatment.According to different ventilation tidal volumes,all patients were divided into a control group and a study group,with 40 patients in each group;The control group chose moderate tidal volume(10ml/kg)for treatment,while the study group chose low tidal volume(6ml/kg)for treatment.Analyze and compare the therapeutic effects of two groups of mechanical ventilation treatments after 48 hours.Results Com-pared with the control group after treatment,the oxygenation index,PaO2 level,and lung compliance of the study group were higher(P＜0.001);PaCO2 levels,CRP,IL-6 levels,and peak airway pressure were lower(P＜0.001).Com-pared with the control group,the study group had shorter mechanical ventilation treatment time and hospitalization time(P＜0.001).The myocardial performance index of the research group after treatment was lower than that of the control group,and the diastolic and systolic blood pressure were higher than those of the control group(all P＜0.001).The incidence of ARDS in the research group was 5.00％,significantly lower than the 22.50％in the control group,and the difference was statistically significant(P=0.043).Conclusion When patients with acute respiratory failure without ARDS receive invasive mechanical ventilation treatment,different tidal volumes have a certain impact on their cardiac function:compared with low tidal vol-umes,moderate tidal volumes can lead to decreased ven-tricular systolic function and have little effect on ventricular diastolic function;Small tidal volume therapy can achieve significant therapeutic effects and significantly improve its prognosis,enabling early recovery.