Efficacy Observation of Bifidobacterium Triple Probiotic Enteric Capsules Combined with Mesalazine in the Treatment of Acute Flares of Ulcerative Colitis

LEI Meng; HAN Kun; WANG Meng

doi:10.13919/j.issn.2095-6274.ZHJY202412026

Abstract：Objective To investigate the effects of a combination of mesalazine and Bifidobacterium triple viable enteric coated capsules on gastrointestinal symptoms and inflammatory cytokine levels in patients with acute exacerbation of ulcerative colitis.Methods Eighty patients with acute exacerbation of ulcerative colitis admitted to the Second Hospital of Xuzhou Mining Group from June 2022 to June 2024 were selected and randomly divided into a control group(40 cases)and an observation group(40 cases)using a random number table.They were treat-ed with mesalazine and combined with Bifidobacterium triple viable enteric capsules,respectively.The efficacy,gastrointestinal symptoms,endoscopic score,colitis activity index(DAI score),and improvement of inflammatory factor levels were compared between the two groups.Results The comparison of therapeutic effects between the two groups was 95.00％vs.80.00％(P＜0.05);Before and after treatment,the scores of various digestive symptoms in the observation group were significantly lower than those in the control group(P＜0.05);After treatment,both en-doscopic and DAI scores significantly decreased(P＜0.05);After treatment,both IL-6 and TNF-α improved com-pared to before treatment,and the improvement in the observation group was greater than that in the control group(P＜0.05).Conclusion The combination of Bifidobacterium triple active bacteria enteric coated capsules and mesalazine treatment is beneficial for improving gastrointestinal symptoms and enteritis activity index,reducing in-flammatory reactions,and has a reliable effect in patients with acute exacerbation of UC.