Efficacy of High-Flow Nasal Oxygen Therapy in Patients with Acute Respiratory Failure Due to Chest Trauma

WANG Aimin; ZHU Guangbing

doi:10.13919/j.issn.2095-6274.ZHJY202412018

Abstract：Objective To investigate the efficacy of high-flow nasal oxygen therapy in patients with acute respiratory failure due to chest trauma,and to further explore its advantages.Methods A retrospective analysis was conducted on the clinical data of 120 patients with acute respiratory failure secondary to chest trauma admitted to Taicang First People's Hospital between March 2019 and March 2023.Based on the differences in oxygen thera-py methods,patients were divided into an observation group(high-flow nasal oxygen therapy,n=60)and a control group(conventional oxygen therapy,n=60).Comparative analyses were performed on blood gas parameters,pul-monary function indicators,respiratory mechanics metrics,and clinical outcomes between the two groups.Re-sults Prior to treatment,there were no significant differences between the two groups regarding blood gas param-eters,which included arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),blood oxygen saturation(SpO2),and pH value.Additionally,pulmonary function indicators such as peak expiratory flow(PEF),forced vital capacity(FVC),and forced expiratory volume in one second(FEV1),along with respira-tory mechanics metrics like peak inspiratory pressure(PIP),airway resistance(Raw),and plateau pressure(Pplat),also showed no significant variation(P>0.05).After treatment,all of these indicators demonstrated significant im-provement in both groups(P<0.05).Moreover,the observation group showed significantly lower levels of arterial partial pressure of carbon dioxide,plateau pressure,and airway pressure compared to the control group(P<0.001).Conversely,the observation group exhibited significantly higher levels of arterial partial pressure of oxygen,blood oxygen saturation,pH value,peak expiratory flow,forced expiratory volume in one second,forced vital capacity,and peak inspiratory pressure(P<0.001).The clinical efficacy rate observed in the observation group was higher than that in the control group(P<0.05).Conclusion High-flow nasal oxygen therapy,combined with timely and effective resuscitative measures,can significantly improve blood gas parameters in patients with acute respiratory failure due to chest trauma,enhance pulmonary function and respiratory capacity to a certain extent,and demonstrate superior clinical efficacy compared to conventional oxygen therapy.