Analysis of Risk and Protective Factors for Major Adverse Cardiovascular Events 2 Years After Drug-Coated Balloon Angioplasty in Acute Myocardial Infarction Patients

ZHANG Dengqin; CAI Wenyu; YE Shengyi; CHEN Zimin

doi:10.13919/j.issn.2095-6274.ZHJY202410019

Abstract：Objective To explore the risk and protective factors associated with major adverse cardiac events(MACE)occurring 2 years after drug-coated balloon(DCB)angioplasty in patients with acute myocardial infarction(AMI).Methods A retrospective analysis was conducted on the clinical data of 78 AMI patients ad-mitted to the Cardiovascular Department of Jinjiang Hospital from January 2023 to August 2024.The data included baseline characteristics,medical history,laboratory test results,lesion vessel location,coronary artery changes,pre-dilatation balloon type,drug-coated balloon usage,and post-procedural outcomes.Based on the occurrence of MACE within 2 years following DCB angioplasty,the patients were divided into two groups:the non-MACE group(54 patients)and the MACE group(24 patients).Logistic regression analysis was performed to identify the factors associated with the occurrence of MACE and to explore potential protective factors.Results Univariate analysis showed that the non-MACE group had lower proportions of intravascular ultrasound(IVUS)guidance,lipoprotein(a)[Lp(a)]levels,and severe coronary artery calcification compared to the MACE group.The proportion of lesions located in the left circumflex artery(LCX)and branch vessels was higher in the non-MACE group than in the MACE group,with statistically significant differences(P<0.05).Multivariate logistic regression analysis revealed that elevated Lp(a)levels,lesions in the LCX,lesions in branch vessels,coronary artery disease involving≥2 vessels,and severe coronary artery calci-fication were independent risk factors for MACE occurring 2 years after DCB angioplasty in AMI patients.Con-clusion High Lp(a)levels,coronary artery disease involving≥2 vessels,and severe coronary artery calcification are independent risk factors for MACE occurring 2 years after drug-coated balloon angioplasty in patients with acute myocardial infarction.In contrast,lesions in the LCX and branch vessels serve as independent protective fac-tors against MACE during this period.