Study on the Efficacy of Arterial Chemotherapy Embolization Combined with Radiofrequency Ablation in the Treatment of Spontaneous Rupture and Bleeding in Hepatocellular Carcinoma

HE Lijun; ZHANG Yu; WU Xingting

doi:10.13919/j.issn.2095-6274.ZHJY202411044

Abstract：Objective This study aims to evaluate the therapeutic effects and clinical value of emergency inter-ventional treatment in patients with spontaneous rupture and hemorrhage due to hepatocellular carcinoma.Methods A retrospective analysis was conducted on the data of 63 patients diagnosed with spontaneous rupture and hemorrhage of hepatocellular carcinoma who were treated at Nanping Second Hospital from June 2021 to June 2024.Patients were categorized into two groups based on the surgical approach:the control group(n=30)underwent arterial chemotherapy embolization,while the observation group(n=33)received a combination of arterial chemotherapy embolization and radiofrequency ablation.The effective hemostasis rate,rate of rebleeding,and incidence of acute liver failure were com-pared between the two groups,along with liver function parameters,tumor markers,and adverse reactions post-treat-ment.Results The observation group demonstrated superior outcomes in terms of effective hemostasis rate and re-bleeding rate compared to the control group,with statistically significant differences(P<0.05).However,the incidence of acute liver failure was more favorable in the control group,though this difference was not statistically significant(P>0.05).Post-treatment,the levels of serum total bilirubin,ALT,and AST in the observation group were significantly lower than those in the control group(P<0.05),while the difference in AFP levels was not statistically significant(P>0.05).Addi-tionally,the incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion The combination of arterial chemotherapy embolization and radiofrequency ablation significantly enhances the treatment efficacy for patients with spontaneous rupture and hemorrhage due to hepatocellular carcinoma.This ap-proach effectively improves liver function and tumor marker levels,reduces the risk of rebleeding,and exhibits a favora-ble safety profile,indicating its substantial clinical value in the emergency management of this condition.