Study on Blood Pressure Changes and the Impact of Antihypertensive Treatment on Cognitive Dysfunction in Patients with Acute Cerebral Infarction and Hypertension

SHU Hailin

doi:10.13919/j.issn.2095-6274.ZHJY202410022

Abstract：Objective To monitor the blood pressure levels of patients with acute cerebral infarction and hypertension at different times,explore the patterns of blood pressure changes,and investigate the advantages of antihypertensive treatment during the acute phase.Methods A retrospective collection of data was conducted on 80 patients with acute cerebral infarction and hypertension admitted to Fujian Medical University Affiliated Min-dong Hospital from January 2023 to June 2024.The patients were divided into a study group(40 cases,treated with antihypertensive therapy)and a control group(40 cases,not treated with antihypertensive therapy)based on wheth-er antihypertensive therapy was performed during the acute phase.Compare the basic data of two groups of study patients,include factors with differences for logistic regression analysis,and explore the related factors of cognitive dysfunction.Results All patients had MAP,SBP,and DBP levels higher than normal upon admission.Among them,57 cases(71.25％)had systolic blood pressure(SBP)≥ 140mmHg and 34 cases(42.50％)had diastolic blood pressure(DBP)≥ 90 mmHg upon admission.Compared with admission,the levels of SBP and mean arterial pres-sure(MAP)significantly decreased on the first day after admission(P＜0.05);On the 7th day after admission,the levels of SBP and DBP significantly decreased(P＜0.05).The levels of MAP,SBP,and DBP significantly decreased within 8 hours of admission and stabilized 48 hours after admission.Multivariate logistic regression analysis found that age ≥ 65 years,MAP ≥ 52 mmHg,hyperuricemia(HUA),hyperhomocysteinemia(HHcy),and C-reactive protein(CRP)＞10 mg/L were independent risk factors for cognitive dysfunction,while education level of high school or above and antihypertensive treatment were inde-pendent protective factors for cognitive dysfunction.Conclusion In patients with acute cerebral infarction and hypertension,actively controlling their blood pressure levels can improve their prognosis and reduce the occurrence of cognitive dysfunction.Age ≥ 65 years,MAP ≥ 52 mmHg,HUA,HHcy,CRP＞10 mg/L are independent risk factors for cognitive impairment,while education level of high school or above and antihypertensive treatment are independent protective factors for cognitive impairment.