Effect of Modified Maxing Shigan Decoction Combined with Ambroxol Hydrochloride on Traditional Chinese Medicine Syndrome Scores in Elderly Patients with Severe Pneumonia of Phlegm-Heat Obstructing the Lungs Type
CHEN Bixia
Abstract：Objective To investigate the clinical efficacy and impact on Traditional Chinese Medicine(TCM)syndrome scores of modified Ma Xing Shi Gan Decoction combined with Ambroxol Hydrochloride in elderly pa-tients with severe pneumonia of the phlegm-heat obstructing the lungs type.Methods A total of 100 elderly patients with severe pneumonia of the phlegm-heat obstructing the lungs type,who visited Zhangzhou Second Traditional Chinese Medicine Hospital from June 2020 to June 2023,were selected for the study.The patients were randomly divided into two groups using a random number table:the observation group(treated with modified Ma Xing Shi Gan Decoction combined with Ambroxol Hydrochloride)and the control group(treated with Ambroxol Hydrochloride alone),with 50 patients in each group.The clinical symptom improvement time,TCM syndrome scores,pulmonary function indicators,inflammatory markers,clinical efficacy,and adverse events were compared and analyzed.Results Compared with the control group,the observation group had significantly shorter times for fever resolution,cough resolution,wheezing resolution,and disappearance of lung rales(P＜0.001).Before treat-ment,there were no significant differences between the two groups in TCM syndrome scores(main symptom score,secondary symptom score,total score),pulmonary function indicators(FEV1,FEV1/FVC,PEF),or inflammatory markers(CRP,IL-6,PCT).After treatment,both groups showed significant reductions in TCM syndrome scores and inflammatory markers(P＜0.001),and significant improvements in pulmonary function indicators(P＜0.001).Additionally,the observation group had lower main symptom scores,secondary symptom scores,total scores,CRP,IL-6,and PCT levels,and higher FEV1,FEV1/FVC,and PEF values compared to the control group.The clinical effective rate was significantly higher in the observation group than in the control group(96.00％vs.82.00％,P=0.025),while the incidence of adverse reactions did not differ significantly between the two groups(14.00％ vs.8.00％,P=0.338).Conclusion For elderly patients with severe pneumonia of the phlegm-heat ob-structing the lungs type,modified Ma Xing Shi Gan Decoction combined with Ambroxol Hydrochloride effectively alleviates clinical symptoms,reduces TCM syndrome scores,improves inflammatory responses,and demonstrates significant clinical efficacy with high safety.
Keywords：modified ma xing shi gan decoctionambroxol hydrochlorideelderly severe pneumonia
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1413-1415,1419 )