Application of Omeprazole Combined with Somatostatin in the Treatment of Acute Upper Gastrointestinal Bleeding

SONG Zehong

doi:10.13919/j.issn.2095-6274.ZHJY202410028

Abstract：Objective This study aims to investigate the efficacy of combined somatostatin and omeprazole treatment in patients with acute upper gastrointestinal bleeding. Methods A retrospective analysis was conducted on the clinical data of 98 patients diagnosed with acute upper gastrointestinal bleeding and treated at the Integrated Traditional and Western Medicine Hospital in Kaiyang County from January 2020 to June 2024. Patients were di-vided into two groups based on their treatment regimen:the study group (n=49) received omeprazole combined with somatostatin,while the control group (n=49) received somatostatin alone. The clinical hemostatic efficacy and asso-ciated indicators,including coagulation,oxidative stress,and inflammation-related markers,as well as the incidence of adverse reactions,were compared between the two groups. Results Following treatment,the overall clinical hemostatic efficacy in the study group was significantly higher than that in the control group (P<0.05). Patients in the study group required significantly less blood transfusion compared to those in the control group (P<0.001),and they experienced shorter hemostatic and hospital stay durations,with significant differences observed (P<0.001). After treatment,prothrombin time,activated partial thromboplastin time,and thrombin time were significantly pro-longed in both groups (P<0.05),while fibrinogen levels significantly decreased (P<0.001). The study group showed superior outcomes in these indicators compared to the control group (P<0.05). Post-treatment,levels of cortisol,antidiuretic hormone,and norepinephrine decreased in both groups (P<0.001),with the study group exhibiting more pronounced reductions (P<0.001). Additionally,levels of procalcitonin,high-sensitivity C-reactive protein,and tumor necrosis factor-α decreased significantly in both groups (P<0.001),with the study group showing significantly greater reductions compared to the control group (P<0.001). The overall incidence of adverse reactions in the study group did not differ significantly from that in the control group (P>0.05). Conclusion The com-bination of somatostatin and omeprazole effectively suppresses the inflammatory response in patients with acute upper gastrointestinal bleeding,alleviates stress responses,facilitates rapid hemostasis,and shortens hospital stays,demonstrating significant clinical efficacy and relatively high safety.