Clinical Analysis of Mycoplasma Pneumonia Combined with Respiratory Syncytial Virus Infection in Pediatric Acute Severe Pneumonia

DENG Pengfei; CHEN Shaohua; LAN Zhenzhang; ZHANG Guanglin; LU Tao

doi:10.13919/j.issn.2095-6274.ZHJY202410031

Abstract：Objective To analyze the clinical characteristics of Mycoplasma pneumonia combined with res-piratory syncytial virus (RSV) infection in children with pneumonia. Methods A total of 130 children with Myco-plasma pneumoniae infection diagnosed with pneumonia were selected from the Pediatric Department of the Second Hospital of Sanming,Fujian Province,between October 2021 and September 2023. Of these,100 children with isolat-ed Mycoplasma pneumonia were assigned to the "monoinfection group" (group 1),and 30 children with both My-coplasma pneumonia and RSV infection were assigned to the "coinfection group"(group 2). The general character-istics,clinical presentations,laboratory results,radiological features,and treatment outcomes of the two groups were compared and analyzed. Results There were no statistically significant differences between the two groups in terms of gender or infection severity (P>0.05). However,the coinfection group was younger than the monoinfection group (P<0.05),and the incidence of severe pneumonia was significantly higher in the coinfection group (P<0.001). A sig-nificant difference in clinical signs and symptoms was observed between the two groups (P<0.05). Within 72 hours of onset,the coinfection group had significantly higher levels of procalcitonin,C-reactive protein,neutrophils,and white blood cells (WBCs) compared to the monoinfection group (P<0.05). The coinfection group also showed a higher rate of lung consolidation and a lower rate of radiological improvement at one week post-treatment (P<0.05). Furthermore,the coinfection group had higher rates of non-invasive respiratory support,oxygen therapy,and severe pneumonia inci-dence,and a longer hospitalization time compared to the monoinfection group (P<0.05). Conclusion Coin-fection with respiratory syncytial virus may exacerbate the condition of children with Mycoplasma pneumonia,leading to more severe clinical manifestations,prolonged hospitalization,and a potentially worse prognosis.