Effect of Doxycycline Combined with Azithromycin on the Recovery Progress of Patients with Scrub Typhus Complicated with Pulmonary Infection

ZENG Huabiao; CHEN Lifang

doi:10.13919/j.issn.2095-6274.ZHJY202411013

Abstract：Objective To analyze the therapeutic effect of the combination therapy of doxycycline and azithromycin in patients with scrub typhus complicated by pulmonary infection. Methods A retrospective col-lection of clinical data was conducted on 100 patients with scrub typhus complicated with pulmonary infection who visited Pingtan Branch of Fujian Union Medical College Hospital from February 2021 to February 2024. The pa-tients were divided into an observation group (50 cases of doxycycline combined with azithromycin) and a control group (50 cases of doxycycline) based on the treatment plan. Compare the clinical efficacy,clinical indicators of rehabilitation time,liver function status,and incidence of adverse reactions between two groups of research sub-jects. Results The total clinical effective rate of the observation group was significantly higher than that of the control group (P>0.05);The observation group showed that the subjects' body temperature returned to normal,lung rales disappeared,scabs fell off,liver function returned to normal,and hospitalization time was shorter (P<0.001). After treatment,the observation group had lower levels of aspartate aminotransferase and alanine aminotransferase (P<0.001). There was no significant difference in the overall incidence of adverse reactions between the two study groups (P>0.05). Conclusion For patients with scrub typhus complicated with pulmonary infection,the combi-nation therapy of doxycycline and azithromycin has significant clinical efficacy,can shorten the improvement time of clinical symptoms to a certain extent,promote the recovery of liver function,and has relatively high safety.