Clinical Efficacy and Safety of Mild Hypothermia Combined with Hyperbaric Oxygen Therapy in the Treatment of Acute Carbon Monoxide Poisoning

WU Yansheng; ZHENG Zhipeng; YU Yigang

doi:10.13919/j.issn.2095-6274.ZHJY202410049

Abstract：Objective Exploring the therapeutic effects of hypothermia and hyperbaric oxygen therapy on emergency acute carbon monoxide poisoning (ACOP) patients. Methods A retrospective analysis was conducted on 100 ACOP patients admitted to our Hospital from January 2020 to September 2024,who were divided into two groups according to different treatment methods. The control group (50 cases) received hyperbaric oxygen therapy,while the observation group (50 cases) received mild hypothermia therapy on this basis. Compare the clinical effica-cy,arterial blood gas indicators (PaO2,PaCO2,COHb,Oxyhemoglobin),National Institutes of Health Stroke Scale (NIHSS),Glasgow Coma Index (GCS),3-month incidence of delayed encephalopathy (DEACMP),24-hour lactate clearance rate,and adverse reactions) between two groups. Results Compared with the control group (72.00％),the total effective rate of the observation group (96.00％) was significantly higher (P<0.05);After 7 days of treat-ment,the observation group had higher levels of PaO2 and OxyHb than the control group,lower levels of PaCO2 and COHb than the control group,lower NIHSS scores than the control group,higher GCS scores than the control group,lower incidence of DEACMP than the control group,and higher 24-hour blood lactate clearance rate than the control group,with statistically significant differences (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The combination of hypothermia and hyperbaric oxygen therapy has a sig-nificant therapeutic effect on ACOP patients,which can effectively improve arterial blood gas indicators,neuro-logical function,and coma degree,reduce the incidence of DEACMP,improve 24-hour blood lactate clearance rate,and is relatively safe.