Value of Combined Diagnosis of Hemolysis Markers,Reticulocytes,and Serum Total Bilirubin in Neonatal Hemolytic Disease

QIU Shanyi

doi:10.13919/j.issn.2095-6274.ZHJY20240835

Abstract：Objective To explore the diagnostic value of the combination of hemolytic markers,reticulocytes,and serum total bilirubin in hemolytic disease of the newborn (HDN). Methods 80 children suspected of neonatal hemolysis who visited Shishi Maternal and Child Health Hospital from March 2021 to March 2024 were selected as the research subjects. According to the gold standard test results,they were divided into hemolytic disease group (n=65) and non hemolytic disease group (n=15). Analyze the diagnostic efficacy of different indicator tests for neonatal hemolysis. Results Out of 80 suspected cases,61 (76.25％) were diagnosed with hemolytic disease of the newborn,while 19 (23.75％) were diagnosed with non hemolytic disease of the newborn. The levels of reticulocytes and serum total bilirubin in the hemolytic disease group were significantly higher than those in the non hemolytic disease group (P<0.001). The sensitivity of the combined diagnosis of the three is significantly higher than that of the diagnosis of individual reticulocytes (P=0.015) and serum total bilirubin (P=0.048);The specificity of the combined diagnosis of the three is significantly higher than that of the diagnosis of individual reticulocytes (P=0.013) and serum total biliru-bin (P=0.031);The accuracy of the combined diagnosis of the three factors is significantly higher than that of hemoly-sis alone (P=0.043),reticulocytes (P=0.001),and serum total bilirubin (P=0.005). Conclusion The combination of the three can significantly improve the early diagnostic efficiency of HDN.