Clinical Correlation Analysis of CRP,Eosinophil,and Neutrophil Changes During Influenza Virus Infection

QIU Sujuan

doi:10.13919/j.issn.2095-6274.ZHJY202409004

Abstract：Objective To investigate the clinical correlation between C-reactive protein (CRP) levels and changes in eosinophils and neutrophils during influenza virus infection. Methods This study employed stratified sampling to select 210 patients diagnosed with influenza virus infection at the First Affiliated Hospital of Xiamen University from January 1,2023,to December 31,2023,as the observation group. Additionally,286 healthy in-dividuals undergoing routine health examinations were selected as the control group. Venous blood samples were collected from both groups to measure CRP levels and the proportions of eosinophils and neutrophils. Pearson correlation analysis was used to explore the relationship between CRP levels and eosinophil and neutrophil counts. Multiple linear regression analysis was employed to investigate the independent association between CRP levels and changes in eosinophils and neutrophils. Results The CRP levels in the observation group were higher than those in the control group (9.3±4.9 vs. 1.9±1.0,P<0.001),and the percentage of neutrophils was also higher in the observation group (59.7±9.8 vs. 54.8±10.2,P<0.001). There was a positive correlation between serum CRP levels and neutrophil counts (r=0.584,P=0.017). Multiple linear regression analysis indicated that neutrophil counts had a significant impact on CRP levels (P=0.015). Conclusion During influenza virus infection,the elevation in CRP levels primarily reflects an acute inflammatory response mediated by neutrophils. This finding is significant for op-timizing the diagnosis and assessment of the clinical status of influenza virus infections.