Effect of Continuous Renal Replacement Therapy on Kidney Function,Inflammatory Markers,and Clinical Scores in Patients with Acute Kidney Injury

SU Xiaoxia

doi:10.13919/j.issn.2095-6274.ZHJY202410023

Abstract：Objective To investigate the effects of blood purification therapy on the treatment outcomes and inflammatory marker levels in patients with acute kidney injury (AKI). Methods A total of 85 patients with acute kidney injury,treated at the Second People's Hospital of Qinzhou from April 2021 to April 2023,were selected and randomly assigned into two groups using a random number table:the control group (42 patients) and the observation group (43 patients). The control group received conventional treatment,while the observation group was treated with continuous blood purification. Kidney function,inflammatory markers,hemodynamic parameters,and SOFA and APACHE Ⅱ scores were compared between the two groups after treatment. Results After treatment,the observa-tion group showed significantly greater reductions in serum creatinine (Scr),blood urea nitrogen (BUN),and cystatin C (Cys-C) levels compared to the control group (P<0.05). Inflammatory markers,including procalcitonin (PCT),tu-mor necrosis factor-alpha (TNF-α),and interleukin-6 (IL-6),were also significantly lower in the observation group (P<0.05). Additionally,the observation group had a significant decrease in PaO2,central venous pressure (CVP),and heart rate (HR) compared to the control group (P<0.05). After treatment,SOFA and APACHE Ⅱ scores in the obser-vation group were significantly lower than those in the control group (P<0.05). Conclusion Blood purification therapy in patients with acute kidney injury can significantly improve kidney function,reduce inflammatory marker levels,enhance hemodynamic stability,and lower SOFA and APACHE Ⅱ scores,which are beneficial for the recovery of organ function. This treatment approach is worthy of clinical application and further promotion.