Diagnostic Value of WBC,CRP,and SAA in Pediatric Acute Respiratory Infections

ZHAO Xiaoxuan

doi:10.13919/j.issn.2095-6274.ZHJY202408013

Abstract：Objective To analyze the diagnostic value of white blood cell(WBC)count,C-reactive protein(CRP),and serum amyloid A(SAA)in differentiating acute respiratory infections in children.Methods A total of 120 children diagnosed with acute respiratory infections from January 2021 to July 2024 at the Fifth Hospital of Zhangzhou,Fujian Province,were selected for this study.They were divided into a bacterial infection group(n=64)and a viral infection group(n=56),with a concurrent control group of healthy children(n=60).Levels of WBC,CRP,and SAA were compared and analyzed for their diagnostic performance both individually and in combina-tion in acute respiratory infections.Results Before treatment,levels of WBC,CRP,and SAA in the bacterial infection group were significantly higher than those in the viral infection group and the healthy control group(all P＜0.05).WBC levels in the viral infection group were lower than those in the healthy control group(P＜0.05),while CRP and SAA levels were higher than those in the healthy group(both P＜0.05).Compared to pre-treatment levels,post-treatment levels of WBC,CRP,and SAA significantly decreased in the bacterial infection group(P＜0.05),and CRP and SAA levels significantly decreased while WBC levels significantly increased in the viral infection group(P＜0.05).The sensitivity,specificity,and accuracy of the combined WBC,CRP,and SAA diagnosis were 89.17％,96.67％,and 91.67％,respectively.The combined diagnostic AUC value for acute respiratory infections in chil-dren was the highest at 0.918;the AUC values for WBC,CRP,and SAA alone were 0.638,0.711,and 0.784,respec-tively.Conclusion The combined use of WBC,CRP,and SAA provides high diagnostic efficacy in differentiat-ing acute respiratory infections in children.