Observational Study on the Efficacy of Corneal Ulcer Debridement Combined with Antifungal Medications in the Treatment of Emergency Fungal Keratitis

ZHANG Xubin; WU Haiying

doi:10.13919/j.issn.2095-6274.ZHJY202407021

Abstract：Objective To analyze the application value of antifungal medications combined with corneal ulcer debridement in the treatment of fungal keratitis.Methods A total of 86 patients with acute fungal kerati-tis treated at Yinchuan Jinchuan Eye Hospital from February 2021 to February 2024 were selected.Patients were randomly assigned to either the experimental group(antifungal medication+corneal ulcer debridement,n=43)or the control group(antifungal medication only,n=43)using a lottery method.Differences between the two groups were compared in terms of symptom resolution time,clinical efficacy,and visual recovery.Results The time required for the resolution of foreign body sensation,photophobia,tearing,purulent discharge,and ulceration in the experimental group was significantly shorter than that in the control group(P＜0.001).In the experimental group,41 patients achieved a total clinical effective rate of 95.35％,significantly higher than the 35 patients in the control group with a clinical effective rate of 81.40％(P＜0.05).Postoperatively,the majority of patients in the experimen-tal group had a visual acuity of 0.5 or above(55.81％),followed by 0.3 to 0.5(30.23％).In contrast,most patients in the control group had a visual acuity between 0.05 and 0.3(34.88％).The visual recovery in the experimental group was significantly better than that in the control group(P=0.001).Conclusion The combination of antifun-gal medications and corneal ulcer debridement is effective in reducing symptom resolution time,improving clinical efficacy,and promoting visual recovery in patients with fungal keratitis.