Observational Study on the Effects of Urapidil and Nitroglycerin in Emergency Management of Hypertensive Crisesemergencies
CAO Jun
Abstract：Objective To analyze the clinical value of a treatment regimen combining urapidil and nitroglyc-erin for patients with hypertensive emergencies.Methods 100 patients with hypertensive emergencies,treated at Wuhan Iron and Steel(Group)Company's Second Workers'Hospital from March 2022 to March 2024,were included in the study.Patients were divided into a trial group(urapidil combined with nitroglycerin,n=50)and a control group(nitroglycerin only,n=50).Clinical efficacy,heart rate,blood pressure,serum creatinine(Scr),and total cholesterol(TC)levels were compared between the two groups.Results Before treatment,there were no significant differences be-tween the two groups in systolic blood pressure,diastolic blood pressure,heart rate,Scr,or TC levels(P＞0.05).After treatment,systolic blood pressure,diastolic blood pressure,heart rate,Scr,and TC levels in both groups decreased sig-nificantly compared to pre-treatment values(P＜0.05),with the trial group showing significantly greater reductions in systolic blood pressure,diastolic blood pressure,heart rate,Scr,and TC levels compared to the control group(P＜0.001).The total clinical efficacy in the trial group was 94.00％(47/50),significantly higher than the 72.00％(36/50)in the control group,with a statistically significant difference(P＜0.05).Conclusion For patients with hypertensive emer-gencies,the treatment regimen combining urapidil and nitroglycerin effectively controls blood pressure,stabilizes heart rate,reduces Scr and TC levels,and demonstrates superior clinical efficacy.
Keywords：hypertensionnitroglycerinheart ratefirst aid
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1071-1073 )