Impact of Early Post～Thrombolysis Transfer for PCI on Cardiac Function and Prognosis in Patients with Acute ST Segment Elevation Myocardial Infarction

REN Juan; CHEN Mai; LUO Ren; LU Hui; XU Feng

doi:10.13919/j.issn.2095-6274.ZHJY202407046

Abstract：Objective This study aims to analyze and discuss the impact of early transfer for percutaneous coronary intervention(PCI)after thrombolysis on cardiac function and prognosis in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods 194 STEMI patients treated at the First Division Hospital of Xinjiang Production and Construction Corps were selected as the study subjects.Based on early reperfusion treat-ment methods,patients were divided into two groups:the control group(92 patients),who were directly admitted to our hospital for PCI without referral,and the observation group(96 patients),who were transferred to our hos-pital for PCI as soon as possible after thrombolysis at a primary care hospital.The study compared the impact of these treatment methods on the timing of medical treatment milestones,ventricular remodeling,cardiac function,the risk of major adverse cardiovascular events(MACE),and survival rates in STEMI patients.Results There was no significant difference between the two groups in the time from symptom onset to the first medical contact(P＞0.05).However,the time from the first medical contact to the initiation of reperfusion and the time from enter-ing the PCI-performing hospital to balloon dilation were significantly shorter in the observation group compared to the control group(P＜0.05).There were no significant differences in left ventricular end～diastolic diameter(LVEDD)or left ventricular ejection fraction(LVEF)between the two groups during hospitalization,at three months,six months,and twelve months post-myocar-dial infarction(P＞0.05).Additionally,there was no significant difference in the incidence of all-cause mortality,cardiovascular mortality,recurrent myocardial infarction,newly diagnosed heart failure requiring treatment,or the total number of MACE events during the follow-up period between the two groups(P＞0.05).Kaplan-Mei-er survival analysis showed no significant difference in the distribution of MACE events between the two groups(P=0.545).Conclusion Early transfer for PCI after thrombolysis at primary care hospitals can shorten the time from medical contact to reperfusion initiation and the door-to-balloon time at the PCI-performing hospital.Com-pared to direct emergency PCI treatment,it does not increase the risk of acute cardiac insufficiency,post-myocardial infarction ventricular remodeling,decline in cardiac function,or MACE events,nor does it reduce survival rates.