Clinical Study of High-Frequency Oscillation Ventilation versus Synchronized Intermittent Mandatory Ventilation in the Treatment of Neonatal Respiratory Distress Syndrome
XIE Na
Abstract：Objective To investigate the efficacy of synchronous intermittent mandatory ventilation(SIMV)versus high-frequency oscillatory ventilation(HFOV)in treating neonatal respiratory distress syndrome(NRDS).Methods A retrospective study was conducted on 80 neonates with NRDS who received either SIMV or HFOV at Zhangzhou Hospital from January 2021 to January 2024.The patients were divided into two groups based on the ventilation method,with 40 cases in each group.The changes in arterial partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2),oxygenation index(OI),fraction of inspired oxygen(FiO2),and mean airway pressure(MAP)were compared between the two groups at different time points.Additionally,the incidence rates of complications were observed and compared between the two groups.Results At 1 hour,6 hours,and 12 hours post-ventilation,the HFOV group had lower PaCO2,FiO2,and OI levels and higher PaO2 levels compared to those of the SIMV group(P＜0.05).At 1 hour,6 hours,12 hours,24 hours,and 48 hours post-ventilation,the MAP in the HFOV group was significantly higher than that in the SIMV group(P＜0.05).The HFOV group also had shorter ventilation duration and hospital stay,as well as lower incidences of pneumothorax,bronchopulmonary dysplasia,hypotension,pulmonary hemorrhage,and intracranial hemorrhage compared to those of the SIMV group(P＜0.05).Conclusion HFOV demonstrates better clinical efficacy and lower complication rates compared to SIMV in the treatment of neonatal respiratory distress syndrome.
Keywords：respiratory distress syndromenewbornhigh-frequency ventilationrespiration
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 790-793 )