The Therapeutic Effect of Sublingual Administration of Captopril Combined with Nicardipine on Subacute Hypertension and the Influence of Ang Ⅱ and ALD Levels
HOU Junling
LI Chunling
Abstract：Objective To analyze the clinical efficacy of sublingual administration of captopril combined with nifedipine in the treatment of hypertensive urgency.Methods 150 patients with hypertensive urgency treat-ed at Shanghe County People's Hospital from October 2020 to September 2023 were selected as the study subjects.They were randomly divided into the observation group and the control group,with 75 cases in each group.The control group received treatment including injection nifedipine and dietary management.The observation group received sublingual administration of captopril in addition to the treatment given to the control group.Clinical effi-cacy was compared between the two groups.Levels of Ang Ⅱ,ALD,renin,adrenocorticotrophic hormone(ACTH),cortisol(Cor),and blood pressure(diastolic and systolic)were analyzed before and after treatment in both groups.Results After treatment,the observation group showed better clinical efficacy compared to the control group,with statistically significant differences(P＜0.05).There were no significant differences in levels of Ang Ⅱ,ALD,renin,ACTH,and Cor between the two groups before treatment(P＞0.05).After treatment,levels of Ang Ⅱ,ALD,renin,ACTH,and Cor decreased more significantly in the observation group compared to the control group(P＜0.05).There were no significant differences in blood pressure levels between the two groups before treatment(P＞0.05).But after treatment,the observation group showed a significantly greater reduction in blood pressure compared to the control group,with statistically significant differences(P＜0.05).Conclusion Sublingual administration of captopril combined with nifedipine achieves favorable efficacy in the treatment of hypertensive urgency,stabilizes blood pressure levels,and reduces levels of Ang Ⅱ,ALD,renin,ACTH,and Cor in patients.
Keywords：captoprilnicardipinehigh blood pressure
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 780-783 )