Study on the Efficacy of Enalapril Maleate and Folic Acid Tablets in Preventing Recurrent Cerebral Infarction in Patients with H-type Hypertension
LAN Xiaoyan
MA Liqin
QIU Yu
SONG Lingling
Huang Yingyu
Abstract：Objective To explore the efficacy of enalapril maleate and folic acid tablets in preventing the recurrence of cerebral infarction in patients with cerebral infarction complicated with H-type hypertension.Methods This study selected 120 patients with cerebral infarction complicated with H-type hypertension who were hospitalized or visited the outpatient clinic at the Neurology Department of Nanning Third People's Hospital from April 2017 to October 2018.The patients were randomly divided into two groups using a digital table method:a mon-otherapy group(10 mg/day enalapril maleate)and a combination group(10 mg enalapril maleate and 0.8 mg folic acid/day).The therapeutic effects,blood pressure,homocysteine(Hcy),blood glucose,blood lipids,and the incidence of cerebral infarction within one year of medication were observed in both groups.Results Compared to the mon-otherapy group,the combination group had a significantly higher overall efficacy rate(P＜0.05).and after treatment,the combination group showed lower levels of diastolic blood pressure,systolic blood pressure,and Hcy(P＜0.05).There were no significant differences in blood glucose and blood lipid levels between the two groups before treatment(P＞0.05).But after treatment,the combination group had significantly lower levels of blood glucose and blood lipids compared to the monotherapy group(P＜0.05).The levels of triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)in the combination group were significantly lower than those in the monotherapy group after treatment(P＜0.05).The incidence of cerebral in-farction within one year of medication was lower in the combination group compared to the monotherapy group(P＜0.05).Conclusion Enalapril maleate and folic acid tablets offer significant advantages in patients with cerebral infarction complicated with H-type hypertension.They effectively reduce blood pressure,blood glucose,blood lipids,and homocysteine levels,and decrease the inci-dence of cerebral infarction,highlighting their therapeutic value and potential for widespread use.
Keywords：brain Infarctionhypertensionfolic acid
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 749-752 )