Clinical Efficacy of Captopril Sublingual Administration in the Treatment of Hypertensive Emergencies

YU Xinxiu; ZHAO Long; LI Yuru; HAN Lei; ZHAO Songqi

doi:10.13919/j.issn.2095-6274.ZHJY202404005

Abstract：Objective Exploring the therapeutic effect of sublingual administration of captopril on hyper-tensive emergencies.Methods Selecting 200 hypertensive emergency patients who visited Taikang Yanyuan Rehabilitation Hospital from August 2019 to August 2022 as the research subjects,they were divided into the ob-servation group(captopril sublingual administration,n=100)and the control group(nifedipine sublingual admin-istration,n=100).The clinical efficacy and adverse reactions of the two groups were compared.Results After 8 weeks of treatment,the blood pressure and clinical symptoms of both groups were improved,and the clinical effective rate of the observation group was higher than that in the control group(P＜0.05).Before treatment,systolic blood pressure,diastolic blood pressure,and heart rate of the two groupshad no significant difference.After treat-ment,systolic blood pressure,diastolic blood pressure,and heart rate of patients were significantly decreased in both groups(P＜0.05),and the degrees of decline of systolic blood pressure,diastolic blood pressure,and heart rate was more significant in the observation group than those in the control group(P＜0.001).There were no significant difference in the incidence of headache,facial flushing,shortness of breath,and rapid heart rate between the two groups(P=0.733).Conclusion Sublingual administration of captopril can stably and effectively reduce blood pressure,slow down heart rate,and has less adverse reactions,which is satisfactory for emergency treatment of hy-pertension.