Analysis of the Clinical Effect of IlaprazoleSodium in the Treatment of Acute Upper Gastrointestinal Bleeding

CHEN Bangjin

doi:10.13919/j.issn.2095-6274.ZHJY202404033

Abstract：Objective To explore the possibility and safety of treating acute gastrointestinal bleeding with ilaprazole sodium.Methods 52 patients with acute upper gastrointestinal bleeding admitted to Xiangqian Central Health Center in Minhou County from July 2021 to July 2022 were selected as the study subjects.They were divided into the ilaprazole sodium group(observation group,n=26)and the omeprazole sodium group(con-trol group,n=26).The effective hemostasis rate,bleeding status,hematocrit,hospitalization,and safety of the two groups were compared.Results There was no significant difference in the effective hemostasis rate between the two groups(88.26％vs 92.31％,x2=0.221,P=0.638)between 23 patients in the observationgroup and 24 pa-tients in the control group.The mean hemostatic time in the ilaprazole sodium group was significantly shorter than that in the omeprazole sodium group[(6.4±0.8)h vs(10.5±1.3)h,t=13.696,P＜0.001],and the mean blood loss in the ilaprazole sodium group was significantly lower than that in the omeprazole sodium group[(198.6±32.1)ml vs(287.7±46.5)ml,t=8.041,P＜0.001],and the incidence of rebleeding in the ilaprazolesodium group was much lower than that in the omeprazole sodium group(3.85％vs23.08％,x2=4.127,P=0.042).There was no significant difference in hemoglobin and hematocrit(P＞0.05)between the two groups before treatment,but after treatment,hemoglobin(t=5.900,P＜0.001;t=0.313,P=0.001)and he-matocrit(t=7.961,P＜0.001;t=10.369,P=0.001)of the two groups were significantly increased,and the hemoglobin level(t=2.562,P=0.007)and hematocrit(t=4.899,P＜0.001)in the ilaprazolesodium group increased more significantlythan that of omeprazole sodium group.The mean length of hospital stay time in the ilaprazole group was shorter than that in the omeprazole group[(7.4士0.9)d vs(9.6±1.2)d,t=7.479,P＜0.001],but the average treatment cost of patients in the ilaprazole sodium group was higher than that in the omeprazole sodium group[(3557.3±452.8)vs(2689.7±366.5),t=7.594,P＜0.001].There were 2 cases of ad-verse reactions in the ilaprazole sodium group and 8 cases in the omeprazole sodium group,and the safety profile of the ilaprazolesodium group was higher than that of the omeprazole sodium group(x2=4.457,P=0.035).Con-clusion The effect of ilaprazole sodium in the treatment of acute upper digestive bleeding is basically the same as that of omeprazole sodium.But compared with omeprazole sodium,ilaprazole sodium has faster hemostasis,shorter hospital stay,less blood loss,lower rebleeding rate,better improvement of hemoglobin and hematocrit,and fewer adverse reactions during use,but the treatment cost is higher.