Observation on the Effect of Clopidogrel Hydrogen Sulfate Tablets Combined with Aspirin Enteric Coated Tablets in the Treatment of Acute Coronary Heart Disease Angina Pectoris

ZHANG Ronghe

doi:10.13919/j.issn.2095-6274.ZHJY202404038

Abstract：Objective To observe the effect of the combined treatment of aspirin sulfate enteric coated tablets and clopidogrel hydrogen sulfate tablets on coronary heart disease angina pectoris patient.Methods we selected 100 patients with coronary heart disease and angina pectoris from January 2023 to December 2023admit-ted to the Dongputou Community Health Service Center in Xiangcheng District,Zhangzhou City,Fujian Province,andthey were divided into two groups:the combined therapygroup and the monotherapy(aspirin enteric-coated tablet only)group,with 50 cases in each group.The frequency,duration,degree of pain,and vital signs of angina pectoris were analyzed.Results Before medication,there was no significant difference in the number of angina attacks,duration,VAS score,heart rate,diastolic blood pressure,systolic blood pressure,LVEF,EDV,and ESV be-tween the two groups of patients(P＞0.05);After medication,in the combined therapy group,the number of angina attacks was less than that in the monotherapy group(P＜0.05),the duration was longer than that in the monotherapy group(P＜0.05),the VAS score,heart rate,diastolic blood pressure,and systolic blood pressure were all lower than those in the monotherapy group(P＜0.05),the LVEF was higher than those in the monotherapy group(P＜0.05),the EDV and ESV were lower than those in the monotherapy group(P＜0.05),and the total effective rate was 96.00％(48/50),which was higher than 84.00％(42/50)in the monotherapy group(P＜0.05).The difference in the incidence of adverse drug reactions between the combination therapy group and the monotherapy group was not signifi-cant(P＞0.05).Conclusion The combination of clopi-dogrel hydrogen sulfate tablets and aspirin enteric coated tablets is more effective than aspirin enteric coated tablets alone in the treatment of coronary heart disease angina.