Clinical Characteristics and Risk Factors of Peptic Ulcer Bleeding in Different States of Helicobacter Pylori Isnfection
XU Dexiang
SONG Conghua
LIN Liping
Abstract：Objective To analyze the HP infection statusof patients with peptic ulcer and bleeding,and to explore its clinical characteristics and risk factors.Methods The clinical data of 256 patients with peptic ulcer and bleeding in the Department of Gastroenterology of the Affiliated Hospital of Putian University from January 2017 to June 2020 were retrospectively analyzed.The patients were divided into the HP-negative group,the HPI group,and the HPⅡ group,and the clinical data of the three groups were compared,and the levels of PG,CD40,DEFA,IL-10,IL-17,and TNF-α in serum were compared.Results The levels of PGⅠ,PGⅡ,and CD40 in the HPI group and the HPⅡ group were significantly higher than those in the HP-negative group(all P＜0.05),while the levels of DEFA in the HPI group and the HPⅡ group were significantly lower than those in HP-negative patients(P＜0.05).The levels of PGⅠ,PGⅡ,and CD40 in the HPⅠ group were significantly higher than those in the HPⅡgroup(P＜0.05),while the levels of DEFA in the HPⅠ group were significantly lower than those in the HPⅡ group(P＜0.05).The levels of IL-10,IL-17,and TNF-α in the HPⅠ group and the HPⅡ group were significantly higher than those in the HP-negative group(all P＜0.05).The levels of IL-10,IL-17,and TNF-α in the HPⅠ group were significantly higher than those in the HPⅡ group(P＜0.05).Conclusion PGⅠ,PGⅡ,CD40,IL-10,IL-17,and TNF-α may be risk factors for peptic ulcer bleeding,and DEFA may be a protective factor for peptic ulcer bleeding.
Keywords：helicobacter pyloripeptic ulcer hemorrhagerisk factors
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 520-523 )