Culture and Drug Sensitivity Analysis of Mycoplasma in Urinary and Reproductive Tract Secretions

WANG Chao

doi:10.13919/j.issn.2095-6274.J202403102

Abstract：Objective To investigate the infection and drug resistance of mycoplasma urogenital tract.Methods 3050 patients visitedgynecology,obstetrics,dermatology,urology,or other departments of our hos-pital were selected as research subjects,and the secretions of urogenital tract were detected for all patients.Results Among the 3050 samples,12 cases of reaction hole color turned turbid red,which belonged to bacterial pollution.Most of the 3038 qualified samples were female,and the positive rate of female mycoplasma culture was 56.87％,among which the positive rate of UU group was 81.23％,accounting for the highest proportion.There was no significant difference in positive rate between MH group,UU group,and UU+MH group(P＞0.05).Most of the qualified speci-mens were from gynecology department,accounting for 74.62％(2267/3038).In UU group,the antimicrobial medi-cines with antimicrobial susceptibility rate exceeded 50％ordered from high to low were doxycycline,minocycline,spectinomycin,and josamycin,and doxycycline and minocycline had the highest susceptibility rate.The antibiotics with drug resistance rate of more than 40％ordered from high to low were azithromycin,clarithromycin,ciproflox-acin,Sparfloxacin,roxithromycin,and azithromycin,and clarithromycin and ciprofloxacin had the highest drug re-sistance rate.Conclusion The study shows that patients with positive mycoplasma culture results in urogenital tract should be treated based on their clinical symptoms,medical history,examination indications and mycoplasma concentration,and other information to make a comprehensive judgment,in order to determine the use and dosage of antibiotics through pharmacokinetics and in vitro drug sensitivity tests.