Correlation Analysis between Subclinical Hypothyroidism during Pregnancy and Preterm Birth

SHI Donghua; NI Jingling

doi:10.13919/j.issn.2095-6274.J202402047

Abstract：Objective To analyze the incidence of subclinical hypothyroidism(abbreviated as hypothyroidism)during pregnancy in pregnant women,and to analyze the correlation between this disease and preterm birth.Methods Using a retrospective research method,pregnant women admitted to Jinjiang Hospital from February 2021 to June 2023 were selected as the study subjects.Clinical symptoms,laboratory examination results,and imaging examination results of the study subjects were collected and organized.Finally,82 patients with gestational hypothyroidism were included in the observation group,and 118 healthy pregnant women without gestational hypothyroidism were included in the control group.We analyze the risk factors for inducing hypothyroidism during pregnancy and the correlation between this disease and preterm birth.Results Univariate analysis showed that there were statistically significant differences between the observation group and the control group in smoking or long-term smoking environment,pregnancy hypertension,placental abruption,premature rupture of membranes,abnormal BMI,history of abortion,gestational diabetes,fetal growth restriction,Hb,TSH,TPOAb,TRAb,and pregnancy outcomes(P＜0.05).Logistic regression analysis showed that diabetes in pregnancy,pregnancy hypertension,smoking or long-term smoking environment,placental abruption,premature rupture of membranes,abnormal BMI,abortion history,fetal growth restriction,Hb＜110g/L,TSH＞3.0mIU/L,TPOAb＞34IU/ml,TRAb＞1.71IU/L were the high-risk factors leading to hypothyroidism in pregnant women(P=0.000).Pearson program analysis shows that preterm birth is negatively correlated with Hb,while preterm birth is positively correlated with TSH,TPOAb,and TRAb.Conclusion Clinical hypothyroidism is closely related to the pregnancy outcome.In order to effectively prevent this problem,we need to strengthen the control of serological indicators such as hypertension,diabetes,TSH,in order to avoid affecting the pregnancy outcome.