The Prognostic Value of Serum Related Indicators and CURB-65 Score in Patients with Acute Severe Pneumonia

KE Jiaming; CHEN Haiyan

doi:10.13919/j.issn.2095-6274.J202402017

Abstract：Objective To evaluate the prognostic value of serum markers combined with CURB-65 in pa-tients with acute severe pneumonia.Methods A retrospective study method was used to study eighty patients with severe pneumonia admitted to the emergency department of our hospital from September 2022 to September 2023.The patients were divided into the survival group(n=55)and the death group(n=25).The serum levels of In-terleukin-6(IL-6)and c-reaction protein(CRP)were IL6.Results The level of CRP in the survival group was(123.15±36.05)mg/l,and that in the death group was(117.15±35.56)mg/l,there was no significant difference between the two groups(P＞0.05).The level of ⅠL-8 in the survival group was(43.05±7.76)pg/ml,while that in the death group was(56.27±10.63)pg/ml.The expression level of Angiopoietin-2(Ang-2)in the survival group was lower than that in the death group(P＜0.05).The level of IL-6 in the survival group was(32.61±6.89)pg/ml,and that in the death group was(41.49±10.48)pg/ml.The severity of pneumonia in the survival group was significantly lower than that in the death group,with statistically significant differences(P＜0.05).Multivariable logistic regression showed that serum levels of IL-6,IL-8,Ang-2,and CURB-65 were risk factors for poor prognosis in patients with acute severe pneumonia.Conclusion The serum levels of IL-6,IL-8,Ang-2 and the severity of pneumonia may be important prognostic factors in patients with severe pneumonia,it is of great clinical significance to evaluate the prognosis of patients with severe pneu-monia in the emergency department.