Effects of Metoprolol Tartrate Combined with Ivabradine Hydrochloride on Cardiac Function in Elderly Patients with Hypertension Complicated with Chronic Heart Failure
HUANG Wenyu
WU Jindong
Abstract：Objective To investigate the effects of metoprolol tartrate combined with Ivabradine hydrochlo-ride on cardiac function,exercise endurance,and plasma N-terminal B-type brain natriuretic peptide(NT-proB-NP)and cardiac troponin Ⅰ(cTnⅠ)levels in elderly patients with hypertension complicated with chronic heart failure.Methods 60 elderly patients with hypertension complicated with chronic heart failure admitted to our hospital from January 2023 to December 2023 were selected as the study objects and randomly divided into two groups:the control group and the combined treatment group.The control group was treated with metoprolol tartrate,while the combined treatment group was treated with Ivabradine hydrochloride.The efficacy of the combination therapy was evaluated by comparing cardiac function markers,exercise endurance,and the changes of plasma levels of NT-proBNP and cTnⅠ between the two groups.Results Compared with using only metoprolol tartrate in the treatment of elderly patients with hypertension complicated with chronic heart failure,metoprolol tartrate combined with ivabradine hydrochloride can significantly improve the cardiac function and exercise endurance,and reduce the levels of plasma N-terminal B-type brain natriuretic peptide precursor(NT-proBNP)and cardiac troponin Ⅰ(cTnⅠ)(P＜0.05).Conclusion Metoprolol tartrate combined with ivabradine hydrochloride can significant-ly improve cardiac function,increase exercise endur-ance,and reduce plasma NT-proBNP and cTnⅠ levels in elderly patients with hypertension complicated with chronic heart failure.
Keywords：metoprolol tartratehydrochloridehypertensionheart failure
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 16-19 )