Investigation on the risk factors related to urolithiasis

ZENG Xianhui; JIANG Dongpeng; GUAN Dehui; CHEN Yang; SUN Yijun

doi:10.13919/j.issn.2095-6274.2016.06.006

Abstract：Objective To investigate the association between urolithiasis patients’ gender, age, predisposing factors, onset seasons and family history.Methods 150 cases of urolithiasis patients with family history, 520 cases of urolithiasis patients without family history and 480 cases of healthy controls were selected for questionnaire survey.Results (1) The morbidity rates of the first-degree relatives and second-degree relatives in the 150 patients with family history were 11.32% (55/486) and 1.92% (27/1403), respectively higher than 1.37% (23/1682) and 0.17% (6/3458) of those without family history (patients without family history and the control group), the differences were all statiscally significant (χ2=1861.772,P<0.001;χ2=4730.517,P<0.001). (2) Among the patients with family history, the mean age of morbidity for the males was (28.7±2.2) years, younger than (42.6±5.2) years of the females, the difference was statiscally significant (t=2.205, P=0.029). Among the patients without family history, the mean age of morbidity for the males was (36.2±4.7), younger than (48.1±2.7) of the females, the difference was statiscally significant (t=2.302,P=0.022). The mean age of morbidity for the males with family history was significantly younger than those without family history [(28.7±2.2)vs (36.2±4.7) years;t=2.765,P=0.006], while the difference of females’ mean age of morbidity between with family history and without it was no statiscally significant [(42.6±5.2)vs (48.1±2.7) years;t=0.628, P=0.531] (3) Among patients with and without family history, difference of morbidity between seasons was no statiscally significant (χ2=1.403, P=0.705), but comparison of total cases between seasons, constituent ratio of case number in summer and autumn was significantly higher than in spring and winter (χ2=38.997,P<0.001). (4) Environmental risk factors, such as less water, high protein diet, infection, being sick-abed, drinking, medication, trauma, metabolic disorders, urinary tract abnormity, etc. have no significant effect on the morbidity respectively between patients with and without family history, while have significant effect on the morbidity respectively between urolithiasis patients and the control group (P<0.001).Conclusions Urolithiasis is a disease that closely related to environmental factors and heredity.