Correlation between T2 mapping in Duchenne muscular dystrophy and clinical motor function
WANG Meihui
DONG Yuru
XIN Jing
NIU Yayun
WU Shiwen
Abstract：Objective To explore the correlation between T2 value and clinical motor function by analyzing T2 mapping of pelvic and thigh muscles in Duchenne muscular dystrophy (DMD).Methods Clinical motor function (9 m walking time, four step time, timed Gower score) in 12 patients with DMD and T2 mapping imaging were evaluated. Pearson correlation and spearman rank were used to analyze correlation between T2 value and clinical motor function of 15 pelvic and thigh muscles.Results The median time of 9 m walking time was 7.72 s (quarterback interval time was 1.19 s); the median time of four steps time was 4.0 s (quarterback interval time was 2.92 s); timed Gower score was (7.73±1.21) s. Great adductor had the highest T2 value, and long adductor had the shortest T2 value. Both long adductor (rs=0.818, P=0.818) and sartorius (rs=0.645,P=0.645) had a positive correlation with 9 m walking time. Vastus intermedius (rs=0.879,P<0.001), rectus femoris (rs=0.867,P=0.001), great adductor (rs=0.855,P=0.001), gluteus maximus (rs=0.818,P=0.002) and vastus lateralis muscle (rs=0.709, P= 0.011), biceps femoris muscle (rs=0.924,P=0.017) and semitendinosus (rs=0.576,P=0.041) were positively correlated with four steps time. Great adductor (rs=0.776,P=0.014), gluteus maximus (rs=0.760,P=0.017), medial vastus muscle (rs=0.790,P=0.011) and long head of biceps (rs=0.803,P=0.009) were positively correlated with timed Gower score.Conclusions T2 mapping imaging is an objective, quantitative and sensitive technology in assessing disease progression of DMD, and great adductor is probably the most ideal index in assessment of clinical movement function.
Keywords：Duchenne muscular dystrophyT2 mappingclinical motor function assessments
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 255-257 )