Research on the correlation between total volatile organic commpounds level in exhale gas and respiratory disease
LIU Jingsha
SUO Shuang
GAO Hongmei
CHEN Wenli
CHEN Xian
ZHANG Ye
TAN Qinghai
GU Ye
ZHANG Jianpeng
Abstract：Objective To explore the correlation between volatile organic conmpounds (VOCs) concentration in human exhale gas and disease, in order to direct early diagnosis of disease.Methods 100 cases of patients with respiratory diseases one a first grade tertiary hospital of Chinese People’s Armed Police Forces were selected as research subjects, and divided into four groups: lung cancer group (n=15), pneumonia group (n=55), pulmonary fibrosis group (n=15) and chronic obstructive pulmonary diseases (COPD) group (n=15);81 cases of healthy medical staff were selected as the control group. Total VOCs concentration in exhaled gas (labeled Pvoc) of all subjects were detected by photoionization detector (PID).Results Compared with the control group, Pvoc of lung cancer group (Z=-2.523,P=0.012), pneumonia group (Z=-4.281,P<0.001), pulmonary fibrosis group (Z=-3.204,P=0.001) and COPD group (Z=-2.644,P=0.008) were obviously decreased, the differences were all statistically significant. Comparison of Pvoc in any two groups of lung cancer group, pneumonia group, pulmonary fibrosis group and COPD group, there were no statistical significance.Conclusions Total VOCs concentration in exhale gas detected by PID has no contribution to the diagnosis of lung cancer, pneumonia, pulmonary fibrosis and COPD.
Keywords：volatile organic compoundsrespiratory diseasephotoionization detector
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 190-192 )