Correlation study between serum N-terminal pro-brain natriuretic peptide levels and condition assessment and prognosis of emergency patients
WANG Zongke
LI Guihua
Abstract：Objective To explore relationship between serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and condition assessment and prognosis of patients in department of emergency. Methods 208 patients from department of emergency were recruited as research objects. Serum level of NT-proBNP was measured and patients were grouped according to acute physiology and chronic health evaluation system Ⅱ (APACHE Ⅱ ) score within the first 24 h after admission. The relationship between serum NT-proBNP and APACHE Ⅱ score, and their relationships with fatality rate and left ventricular ejection fraction (LVEF) of emergency patients were analyzed. Results Serum NT-proBNP levels showed statistically significant differences among different APACHEⅡscore groups (χ2=68.07, P<0.01). The level of serum NT-proBNP was positively correlated with APACHE Ⅱ score (rs=0.60,P < 0.01). Patients were followed up for 3 months, NT-proBNP level (Z=6.50,P < 0.01) and APACHE Ⅱ score (t’=-16.65,P < 0.01) in death group were significantly higher than those in survival group (P < 0.05). NT-proBNP level in group LVEF ≤ 50% was higher than that in group LVEF > 50%(Z=7.72,P < 0.01), but the difference of APACHE Ⅱ score between two groups had no statistical significance. Conclusions Serum NT-proBNP level is positively correlated with patient’s condition and fatality rate, and may be applied to evaluate condition and prognosis of emergency patients.
Keywords：N-terminal pro-brain natriuretic peptideemergency patientscondition assessmentprognosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 9-11 )