Effects of chemokines in the formation and development of malignant tumor
SUN Dengqun
Abstract：Chemokines are a group of low molecular weight proteins with chemotactic functions that control the migration of cells between tissues and corresponding parts, and interactions of cells within tissue. Initially chemokines were appreciated as important mediators for immune cell migration. In recent years the important roles that chemokines play in the malignant tumor growth and progression have been acknowledged. Chemokines can directly modulate the growth of tumors by inducing the proliferation of cancer cells and preventing their apoptosis. They also direct tumor cell movement as required for metastasis. The author reviewed the research progresses of chemokines in malignant tumor formation and progression, for further understanding of the mechanisms of growth, angiogenesis, invasion and metastasis of tumor that mediated by chemokines.And ultimately provide new therapeutic strategies for malignant tumor patients.
Keywords：chemokineschemokine receptorsmalignant tumor
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 696-700 )